The 84-year-old served in numerous Republican administrations, helping to shape American foreign policy for decades.
“We have lost a remarkable and loving husband, father, grandfather and a great American,” they added.
The family said that Gen Powell was fully vaccinated.
He served in combat during the Vietnam War and later became the first Black national security adviser in the administration of President Ronald Reagan. When Mr Reagan’s Vice President George HW Bush took over, Gen Powell became the youngest and first African American chairman of the Joint Chiefs of Staff.
Gen Powell would later say that pushing faulty intelligence at the United Nations to advocate for the Iraq War as George W Bush’s Secretary of State was a “blot” on his record.
Source: The Independent